Assessment of violations of critical organs and systems in children with a high content of chromium in the blood

Introduction. Chromium (VI) is a common component of emissions from woodworking enterprises and an extremely dangerous polytropic toxic chemical substance that has a sensitizing, mutagenic and carcinogenic effect. 

The aim of the study was to assess disorders of critical organs and systems in children with an increased chromium content in the blood. 

Materials and methods. The content of chromium in the blood was investigated, the values ​​of clinical and biochemical parameters were estimated, the statistical processing of the data was carried out using the Statistica 10 software. 

Results. The level of chromium in the blood of children from the observation group was 2.4 times higher than in the control group. In children with an increased concentration of chromium in the blood, compared with children in the control group, a significant increase in IgE of total, eosinophilic-lymphocytic index, total and direct bilirubin, low-density lipoprotein, α-amylase and LDH was found to be higher by 1.2-3.1 times. TSH, and a 1.2-fold lowering of HDL cholesterol. Significant relationships were obtained between an increased concentration of chromium in the blood and an increased level of IgE total, eosinophilic-lymphocytic index, α-amylase and TSH (R² = 0.20-0.31, p <0.05), lowered HDL cholesterol (R² = 0.89; p <0.05). The dependence of the frequency of occurrence of allergic rhinitis, cardiomyopathy and diseases of the biliary tract (R² = 0.20-0.96; p <0.05) on the increased level of chromium in the blood was established. 

Conclusion. It is advisable to use the obtained biomarkers of adverse effects to increase the efficiency and form medical and prophylactic programs to reduce the level of chromium in the blood and prevent the negative consequences of its impact on the population.

Contribution:

Perezhogin A.N. — the research concept and design, collection literature, writing the text;

Zemlyanova M.A. — the research concept and design, editing;

Koldibekova Yu.V. — the concept and design of the study, statistical processing of the material, writing the text;

Pustovalova O.V. — collection and processing of material. 

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: July 8, 2021 / Accepted: September 28, 2021 / Published: October 31, 2021