Assessment of the influence of pesticides based on glyphosate on the health of agricultural producers

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Abstract

Introduction. The results of a hygienic risk assessment of the use of pesticides based on glyphosate in agricultural production are presented. The study of the pathogenetic mechanisms of action on the body of widely used glyphosate-containing herbicides and the search for markers of health conditions that change under the influence of these drugs are of increasing interest for the early diagnosis of pathological processes and the prevention of occupational and occupational diseases.

The aim of this study was to assess the health effects of glyphosate-based pesticides on the health of operators in an agricultural environment.

Materials and methods. The clinical material for the study was the plasma and erythrocytes of the peripheral blood of operators in contact with glyphosate-containing pesticides. As a control group, 20 clinically healthy individuals of the same age group, who had no contact with the studied pesticides, were selected. There were assessed leading indices of general clinical and biochemical blood tests and markers of endogenous intoxication and oxidative stress.

Results. There were established acceptable risk of exposure to pesticides on workers, subject to compliance with technological regulations and safety requirements. Minor deviations of indicators of general and biochemical blood tests were revealed. A statistically significant increase in the total level of carbonyl derivatives compared to control was obtained among operators who had more substantial contact with glyphosate-containing pesticides.

Conclusion. Working conditions when using preparations in the form of aqueous solutions containing glyphosate, using ground-based spraying of steam fields with a consumption rate of 8 l / ha, subject to compliance with regulations and safety measures, comply with hygienic requirements. The established statistically significant changes in the blood parameters of the operators in comparison with the control group indicate the presence of a risk to the health for workers in contact with glyphosate-containing pesticides and indicates the need for additional biochemical studies during periodic medical examinations of agricultural workers for the early detection of deviations in the health state caused by exposure to pesticides, including those containing glyphosate.

Contribution:

Miroshnikova D.I. — the concept and design of the research, collection and processing of material, statistical processing, writing the text;

Rakitskii V.N. — the concept and design of the research, editing;

Bereznyak I.V. — collection and processing of material, writing the text;

Ivanova L.G. — editing.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

 

About the authors

Darya I. Miroshnikova

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Author for correspondence.
Email: d.i.miroshnikova9@gmail.com
ORCID iD: 0000-0001-5648-6669

MD, PhD-student, Junior Researcher, Department of Toxicology and Environmental Hygiene, Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Mytishchi, 141014, Russian Federation.

e-mail: d.i.miroshnikova9@gmail.com 

Russian Federation

Valerii N. Rakitskii

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9959-6507
Russian Federation

Irina V. Bereznyak

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0001-9501-092X
Russian Federation

Lubov’ G. Ivanova

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-6512-048X
Russian Federation

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