Cardiovascular risk factors in metalworking industry workers

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Abstract

Introduction. Many cardiovascular risk factors are associated with non-alcoholic fatty liver disease, which is recognized as one of the predictors of cardiovascular diseases. Considering non-alcoholic fatty liver disease to be asymptomatic for a long time, it is very important to determine the relationships between various factors involved in the formation of pathology to early detect and prevent cardiovascular diseases in people of working age.

Materials and methods. As part of a cross-sectional study, the prevalence of cardiovascular risk factors in metalworking workers was studied. The body mass index, lipid profile indicators, glucose, glycated hemoglobin, liver ultrasound results, lipid accumulation index, physical activity were analyzed.

Results. The study revealed the presence of liver steatosis in 37% of the study participants. In 19%, liver steatosis was detected with a normal body mass index with a predominance in the “elderly” group; the values of the lipid profile are statistically significantly higher in the group of people diagnosed with liver steatosis: total cholesterol (p < 0.001), triglycerides (p < 0.001), atherogenicity index (p < 0.001); and hyperglycemia (p < 0.001). The coefficient of lipid accumulation increases with age, presence of steatosis, and obesity. In the group of persons with hepatic steatosis, persons with low physical activity significantly predominate.

Limitations. The study has regional (Saratov region) and occupational (workers of the metalworking industry) limitations.

Conclusion. The results of the study showed a high prevalence of liver steatosis among metalworking workers, mainly in elderly men. The established interrelations of the studied cardiovascular risk factors confirm significant cardiometabolic disorders in metalworking workers, which, under conditions of additional exposure to production factors, can potentiate the development of cardiovascular diseases and their complications, cause fatal cases, including at work.

Compliance with ethical standards. Research was conducted in compliance with the requirements of confidentiality of personal data, ethical standards, and principles for conducting medical research involving humans, set out in the Declaration of Helsinki of the World Medical Association of the latest (2008) revision. The study was carried out with the permission of the local ethical committee of the Saratov MNC of Hygiene of the Federal State Budgetary Institution "FNC of Medical and Preventive Technologies of Public Health Risk Management" (Protocol No. 11 of 01.08.2022).

Patient consent. Each participant of the study (or his/her legal representative) gave informed voluntary written consent to participate in the study and publish personal medical information in an impersonal form in the journal "Gigiena i Sanitariya (Hygiene and Sanitation, Russian journal)".

Contribution:
Zaikina I.V. — the concept and design of the study, collection and processing of material, writing a text;
Komleva N.E. — the concept and design of the study, editing;
Mazilov S.I. — collection and processing of material, statistical processing;
Pozdnyakov M.V. — collection and processing of material, writing a text;
Raykin S.S. — collection and processing of material, statistical processing;
Dolich V.N. — collection and processing of material, statistical processing;
Raikova S.V. — collection and processing of material, writing a text.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version. 

Conflict of interest. The authors declare no conflict of interest.

Acknowledgment. The study had no sponsorship. 

Received: October 11, 2022 / Accepted: December 8, 2022 / Published: January 12, 2023 

About the authors

Inna V. Zaikina

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Author for correspondence.
Email: innaza2@mail.ru
ORCID iD: 0000-0003-4234-7056

MD, PhD, Senior Research Officer, Department of Medical Preventive and Innovative Technologies, Saratov Hygiene Medical Research Center of the Federal Scientific Center Medical and Preventive Health Risk Management Technologies, Saratov, 410022, Russian Federation.

e-mail: innaza2@mail.ru

Russian Federation

Nataliia E. Komleva

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; Saratov State Medical University named after V.I. Razumovsky

Email: noemail@neicon.ru
ORCID iD: 0000-0003-4099-9368
Russian Federation

Svyatoslav I. Mazilov

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-8220-145X
Russian Federation

Michail V. Pozdnyakov

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2067-3830
Russian Federation

Sergey S. Raykin

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5817-2994
Russian Federation

Vladimir N. Dolich

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-8980-5117
Russian Federation

Svetlana V. Rajkova

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; Saratov State Medical University named after V.I. Razumovsky

Email: noemail@neicon.ru
ORCID iD: 0000-0001-5749-2382
Russian Federation

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Copyright (c) 2023 Zaikina I.V., Komleva N.E., Mazilov S.I., Pozdnyakov M.V., Raykin S.S., Dolich V.N., Rajkova S.V.


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