Role of intercellular adhesion molecules and antibodies to oxidized LDL in pathogenesis of cardiovascular diseases under mercury exposure

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Abstract

Introduction. Exposure to mercury and its compounds can be a risk factor for the development of cardiovascular diseases.

The aim of the study is to investigate the levels of antibodies to oxidized LDL, intercellular adhesion molecules sICAM-1, sVCAM-1, and VEGF in individuals exposed to mercury.

Material and Methods. A cross-sectional examination was carried out using biochemical methods in persons who have come into contact with metallic mercury with a work experience of more than five years, persons with a first established diagnosis of chronic mercury intoxication, and patients with chronic mercury intoxication in the long-term postexposure period.

Results. In persons exposed to mercury with concomitant cardiovascular diseases, the level of sVCAM-1 differed depending on the presence/absence of intoxication and acquired maximum values in its long-term period, while the concentrations of sICAM-1 and antibodies to oxidized LDL did not differ significantly. In the groups without cardiovascular pathology exposed to mercury, the concentration of sVCAM-1 was higher in patients with intoxication, and sICAM-1 was 1.5-2 times lower when compared with experienced individuals, the level of antibodies to oxidized LDL was maximum in the presence of intoxication in its initial period.

Discussion. The progression of chronic mercury intoxication is accompanied by an increase in the level of sVCAM-1, and a gradual decrease in the content of sICAM-1 to reference values. Trained workers were found to have elevated sICAM-1 levels.

Conclusion. The role of antibodies to oxidized LDL, intercellular adhesion molecules is their multidirectional participation in the mechanisms that inhibit or contribute to the formation of cardiovascular pathology in individuals exposed to mercury.

About the authors

Olga V. Naumova

East-Siberian Institute of Medical and Ecological Research

Author for correspondence.
Email: naumova-olga-v@mail.ru
ORCID iD: 0000-0002-5353-2268

MD, junior research associate. immuno-biochemical and molecular genetic research in hygiene. East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.

e-mail: Naumova-Olga-V@mail.ru

Russian Federation

Irina V. Kudaeva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5608-0818
Russian Federation

Lyudmila B. Masnavieva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1400-6345
Russian Federation

Olga A. Dyakovich

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4903-1401
Russian Federation

References

  1. Efimova N.V., Rukavishnikov V.S. Medical and environmental assessment of mercury hazard for the population of the Irkutsk region. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2001; 89(3): 19–21. (in Russian)
  2. Clarkson T.W., Magos L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 2006; 36(8): 609–62. https://doi.org/10.1080/10408440600845619
  3. Kakita A., Wakabayashi K., Su M., Yoneoka Y., Sakamoto M., Ikuta F., et al. Intrauterine methyl mercury intoxication Consequence of the inherent brain lesions and cognitive dysfunction in maturity. Brain Res. 2000; 877: 322–30. https://doi.org/10.1016/s0006-8993(00)02717-7
  4. Takeushi T., Eto K., Kinjo Y., Tokunago H. Human brain disturbance by methylmercury poisoning, focusing on the long-term effect on brain weight. Neurotoxicology. 1996; 17(1): 187–90.
  5. Ilardi D. Danger: mercury is hazardous to our health. School Nurse News. 2003; 20(4): 24–6.
  6. Massaroni L., Rossoni L.V., Amaral S.M., Stefanon I., Oliveira E.M., Vassallo D.V. Hemodynamic and electrophysiological acute toxic effects of mercury in anaesthetized rats and in langendorff perfused rat hearts. Pharmacol. Res. 1995; 32(1-2): 27–36. https://doi.org/10.1016/s1043-6618(95)80005-0
  7. Rossoni L.V., Amaral S.M., Vassallo P.F., Franca A., Oliveira E.M., Varner K.J., et al. Effects of mercury on the arterial blood pressure of anesthetized rats. Braz. J. Med. Biol. Res. 1999; 32(8): 989–97. https://doi.org/10.1590/s0100-879x1999000800009
  8. Kurlyandskiy B.A., Khamidulina Kh.Kh., Kudinova O.N. Current trends in the industrial development of Russia and toxicological problems of chemical safety. Toksikologicheskiy vestnik. 2005; (1): 2–14. (in Russian)
  9. Nash J.R., Revesz R.L. Market and geography: designing marketable permit schemes to control local and regional pollutants. Ecology L.Q. 2001; 28: 569.
  10. Jansson G., Harms-Ringdahl M. Stimulating effects of mercuric and silver ions on the superoxide anion production in human polymorphonuclear leukocytes. Free Radic. Res. Commun. 1993; 18(2): 87–98. https://doi.org/10.3109/10715769309147345
  11. Clarkson T.W., Magos L., Myers G.J. The toxicology of mercury-current exposures and clinical manifestations. N. Engl. J. Med. 2003; 349(18): 1731–7. https://doi.org/10.1056/NEJMra022471
  12. Hylander L.D., Goodsite M.E. Environmental costs of mercury pollution. Sci. Total Environ. 2006. 368(1): 352–70. https://doi.org/10.1016/j.scitotenv.2005.11.029
  13. Markov Kh.M. Molecular mechanisms of dysfunction of vascular endothelium. Kardiologiya. 2005; 45(12): 62–7. (in Russian)
  14. Touyz R.M. Oxidative stress and vascular damage in hypertension. Curr. Hypertens. Rep. 2000; 2(1): 98–105. https://doi.org/10.1007/s11906-000-0066-3
  15. Vel’kov V.V. Part 2 Where you go, laboratory diagnostics: What to do with new biomarkers. Kliniko-laboratornyy konsilium. 2011; 38(2): 38–42. (in Russian)
  16. Koval’ S.N., Snegurskaya I.A., Mysnichenko O.V. The vascular endothelial growth factor family and its possible role in the hypertension pathogenesis. Arterial’naya gipertenziya. 2012; (4): 85–93. (in Russian)
  17. Rebrova O.Yu. Statistical Analysis of Medical Data. Application of Software Package STATISTICA [Statisticheskiy analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA]. Moscow: MediaSfera; 2006. (in Russian)
  18. Lopes-Virella M.F., Virella G. Clinical significance of the humoral immune response to modified LDL. Clin. Immunol. 2010; 134(1): 55–65. https://doi.org/10.1016/j.clim.2009.04.001
  19. Hansson G.K., Hermansson A. The immune system in atherosclerosis. Nat. Immunol. 2011; 2(3): 204–12. https://doi.org/10.1038/ni.2001
  20. Deneva-Koycheva T.I., Vladimirova-Kitova L.G., Angelova E.A., Tsvetkova T.Z. Serum levels of sICAM-1, sVCAM-1, sE-selectin, sP-selectin in healthy Bulgarian people. Folia Med. (Plovdiv). 2011; 53(2): 22–8. https://doi.org/10.2478/v10153-010-0033-y
  21. Hwang S.J., Ballantyne C.M., Sharrett A.R., Smith L.C., Davis C.E., Gotto AM., et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases. Circulation. 1997; 96(12): 4219–25. https://doi.org/10.1161/01.cir.96.12.4219
  22. Miles E.A., Thies F., Wallace F.A., Powell J.R., Hurst T.L., Newsholme E.A., et al. Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin. Sci. (Lond). 2001; 100(1): 91–100.
  23. Morisaki N., Saito I., Tamura K., Tashiro J., Masuda M., Kanzaki T., et al. New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis. 1997; 131(1): 43–8. https://doi.org/10.1016/s0021-9150(97)06083-8
  24. Rohde L.E., Lee R.T., Rivero J., Jamacochian M., Arroyo L.H., Briggs W., et al. Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 1998; 18(11): 1765–70. https://doi.org/10.1161/01.atv.18.11.1765
  25. Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and it is receptors. Nat. Med. 2003; 9(6): 669–76. https://doi.org/10.1038/nm0603-669
  26. Andrae J., Gallini R., Betsholtz C. Role of plateletderived growth factors in physiology and medicine. Genes Dev. 2008; 22(10): 1276–312. https://doi.org/10.1101/gad.1653708
  27. Przybylski M. A review of the current research on the role of bFGF and VEGF in angiogenesis. J. Wound Care. 2009; 18(12): 516–9. https://doi.org/10.12968/jowc.2009.18.12.45609
  28. Naumova O.V., Kudaeva I.V., Masnavieva L.B., D’yakovich O.A. Markers of vascular tone and inflammation in persons exposed to mercury. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2019; 98(10): 1079–84. (in Russian)
  29. Kudaeva I.V. Role of oxidativs stress in occupational disease pathogenesis осcured after exposure to toxic substances. Vestnik novykh meditsinskikh tekhnologiy. 2009; 16(S1): 253–4. (in Russian)
  30. Kudaeva I.V., Budarina L.A., Masnavieva L.B. Patterns of biochemical disorders under exposure to neurotoxic chemicals varying in nature. Meditsina truda i promyshlennaya ekologiya. 2008; (8): 7–11. (in Russian)
  31. Popkova O.V., Kudaeva I.V., Masnavieva L.B. Some approaches to determining the endothelial dysfunction in occupational diseases of toxic etiology. Meditsinskiy alfavit. Sovremennaya laboratoriya. 2012; (4): 45–7. (in Russian)
  32. Lakhman O.L., Katamanova E.V., Rusanova D.V., Konstantinova T.N., Shevchenko O.I., Kartapol’tseva N.V., et al. Clinic, Diagnosis of Disorders in the Long-Term Period of Professional Neurointoxication [Klinika, diagnostika narusheniy v otdalennom periode professional’nykh neyrointoksikatsiy]. Irkutsk; 2010. (in Russian)
  33. Festa A., Kopp H.P., Schernthaner G., Menzel E.J. Autoantibodies to oxidised low density lipoproteins in IDDM are inversely related to metabolic control and microvascular complications. Diabetologia. 1998; 41(3): 350–6. https://doi.org/10.1007/s001250050914
  34. Garrido-Sánchez L., García-Fuentes E., Cardona F., Rojo-Martínez G., Soriguer F., Tinahones F.J. Anti-oxidized LDL antibody levels are reduced in women with hypertension. Eur. J. Clin. Invest. 2009; 39(9): 800–6. https://doi.org/10.1111/j.1365-2362.2009.02156
  35. Kjaergaard A.G., Dige A., Krog J., Tønnesen E., Wogensen L. Soluble adhesion molecules correlate with surface expression in an in vitro model of endothelial activation. Basic Clin. Pharmacol. Toxicol. 2013; 113(4): 273–9. https://doi.org/10.1111/bcpt.12091
  36. Garton K.J., Gough P.J., Raines E.W. Emerging roles of ectodomain shedding in the regulation of inflammatory responses. J. Leukoc. Biol. 2006; 79(6): 1105–16. https://doi.org/10/1189/jlb.0106038
  37. Petrishchev N.N., Vasina L.V. Disorders of adhesive activity as a form of endothelial dysfunction. Translyatsionnaya meditsina. 2014; (3): 5–15. https://doi.org/10.18705/2311-4495-2014-0-3-5-15 (in Russian)

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