Assessment of disorders of carbohydrate and fat metabolism in children under conditions of oral exposure to organochlorine compounds

Introduction. The authors performed a hygienic and epidemiological study of the Perm Territory areas with unfavorable sanitary and
hygienic indices.

Material and methods. The study involved 7,775 children aged from 4 to 14 years (9.2 ± 3.7 years) living in territories using sodium hypochlorite or liquid chlorine (Perm, Krasnokamsky, Nytvensky districts). The comparison group consisted of 425 children (average age 9.3 ± 2.5 years) consuming drinking water that complies with hygienic standards (Sivinsky, Karagai districts).

Results. Identified areas with low quality of drinking water supply due to the content of organochlorine compounds (OCS) appeared to have an increased prevalence of obesity, diabetes, ischemic, and hypertensive disease. The authors developed and tested the critical assessment of the risk of formation disorders of fat and carbohydrate metabolism in children consuming drinking water with a high content of organochlorine compounds. Under conditions of oral exposure to OCS (0.43-0.64 mg/l, more than 3 MPC), the index of the risk of impaired fat and carbohydrate metabolism in children (IPI 0.55) was 1.3 times higher than the corresponding levels in the territory of comparison (IPI 0,42).

Conclusion. The main markers for the indices of the negative impact of HOS (primarily chloroform) include an increase in the blood level of triglycerides (PS 0.41), LDL (PS 0.25) and a decrease in HDL (PS 0.18), exceeding 1, 2-1.6 times the territory of comparison.