Assessment of the content of toxic and essential elements in the urine of children residing in rural and industrial regions in Western Urals
- Authors: Ulanova T.S.1, Zaitseva N.V.1,2, Veikhman G.A.3, Stenno E.V.1, Nedoshitova A.V.1, Volkova M.V.1
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Affiliations:
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
- E.A.Wagner Perm State Medical University
- Perm State Pharmaceutical Academy
- Issue: Vol 99, No 11 (2020)
- Pages: 1252-1257
- Section: HYGIENE OF CHILDREN AND ADOLESCENTS
- Published: 24.12.2020
- URL: https://rjsocmed.com/0016-9900/article/view/638465
- DOI: https://doi.org/10.47470/0016-9900-2020-99-11-1252-1257
- ID: 638465
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Full Text
Abstract
Introduction. The element composition of urine is relevant and demanded index in biomedical, biomonitoring studies to assess the level of contamination of biological media and public health risks.
Material and methods. The content of 12 elements (V, Cr, Mn, Ni, Cu, Zn, As, Se, Sr, Cd, Tl, Pb) in urine of unexposed children (n = 100 and n = 57, respectively, average age < 6 years) residing in the rural and industrial region of the Western Urals was determined by ICP-MS using Agilent 7500cx inductively coupled plasma quadrupole mass spectrometer (Agilent Technologies, USA) with an octopole reaction / collision cell (ORS). The measurement was carried out according to Methodical Guidelines 4.1. 3230-14 (FR.1.31.2014.17064) developed by the authors. Urine samples were directly analyzed after 1/10 dilution (V / V) with 1% nitric acid solution. The validity of the results was confirmed by analysis of standard urine samples SERONORMTM urine (Norway). The results were presented as basic statistical indices: minimum and maximum values, arithmetic mean (AM), geometric mean (GM), 5th, 50th, 95th percentiles, and were interpreted in accordance with current international requirements.
Results. In the unexposed group of children the arithmetic mean (AM) for vanadium is 0.68 μ/l; chromium - 1.91 μg/l; manganese 0.96 - μg/l; nickel - 1.84 μg/l; copper - 13.28 μg/l; zinc - 270.56 μg/l; arsenic - 18.- 99 μg/l; selenium - 22.55 μg/l; strontium - 239.09 μg/l; cadmium - 0.12 μg/l; thallium - 0.16 μg/l; lead - 0.83 μg/l. The arithmetic mean in the group of children of the industrial territory for vanadium is - 0.72 μg/l; chromium - 2.13 μg/l; manganese - 1.11 μg/l; nickel - 2.76 μg/l; copper - 26.67 μg/l; zinc - 482.1 μg/l; arsenic - 10.09 μg/l; selenium - 32.84 μg/l; strontium - 1275.35 μg/l; cadmium - 0.122 μg/l; thallium - 0.16 μg/l; lead - 2.16 μg/l. Evaluation of the results of the study showed AM excess of nickel, copper, zinc, strontium and lead.
Conclusion. The paper presents regional features of the urine elemental composition in children who permanently reside in Western Urals’ rural and industrial areas. The study results based on the 95 percentile (P95) can be used as approximate reference data as a basis for assessing the risk associated with exposure to metals. The comparative evaluation of the obtained results with the reference concentrations used in Europe, the USA and Canada for national human biomonitoring programs was carried out.
About the authors
Tatyana S. Ulanova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Author for correspondence.
Email: ulanova@fcrisk.ru
ORCID iD: 0000-0002-9238-5598
MD, Ph.D. DSci., Head of the Department of Chemical and Analytical Research Methods Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045,Russian Federation.
e-mail: ulanova@fcrisk.ru
Russian FederationNina V. Zaitseva
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; E.A.Wagner Perm State Medical University
Email: noemail@neicon.ru
ORCID iD: 0000-0003-2356-1145
Russian Federation
Galina A. Veikhman
Perm State Pharmaceutical Academy
Email: noemail@neicon.ru
ORCID iD: 0000-0002-8490-7624
Russian Federation
Elena V. Stenno
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5772-2379
Russian Federation
Anna V. Nedoshitova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID iD: 0000-0001-6514-7239
Russian Federation
Marina V. Volkova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0600-4075
Russian Federation
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