Mechanisms of physiological and toxic effects of lithium salts on the body (literature review)

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Abstract

The study of the influence of various chemical elements on the human body is an important direction because it allows determining the patterns of the distribution and migration of these elements in tissues, as well as their role in the development of specific diseases. Among inorganic chemical compounds, a special place is occupied by lithium salts, which are widely used in industry, agriculture, and medicine. The search and selection of literature sources to identify the physiological effects and characteristics of the toxic effects of lithium salts on the human body and experimental animals was carried out using the bibliographic databases: Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, RSCI, Cyberleninka. Data analysis has showed lithium salts to be classified as moderately hazardous substances (hazard class 3) and in high concentrations have a damaging effect on the functions of the nervous system, kidneys, thyroid and parathyroid glands.

Contribution:
Gorokhova L.G. — the concept of the study, collection of material, writing the text;
Zhukova A.G. — collection of material, writing the text;
Mikhailova N.N. — editing;
Korsakova T.G. — collection of material.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: February 15, 2024 / Revised: March 11, 2024 / Accepted: April 9, 2024 / Published: May 8, 2024

About the authors

Larisa G. Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”

Author for correspondence.
Email: ponomarikova@mail.ru
ORCID iD: 0000-0002-0545-631X

MD, PhD, DSci., Leading researcher, Lab. molecular genetic and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation; Associate Professor of the department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

e-mail: ponomarikova@mail.ru

Russian Federation

Anna G. Zhukova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4797-7842

MD, PhD, DSci., Associate Professor, Head of the Lab. of molecular genetics and experimental research of Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation, Head of the Department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

Russian Federation

Nadezhda N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1127-6980

MD, PhD, DSci., Professor, Chief researcher of the Lab. of molecular genetics and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, 654041, Novokuznetsk, Russian Federation

Russian Federation

Tatyana G. Korsakova

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0003-2512-2541

MD, PhD, leading researcher of the Lab. of Human Ecology and Environmental Hygiene of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation

e-mail: ecologia_nie@mail.ru

Russian Federation

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