电邮这篇文章 Protective influence of coded amino acids on the development of liver tissue culture in the presence of cytostatic
- 作者: Chalisova N.I.1,2, Kozlov V.K.3, Mulik A.B.3, Zatsepin E.P.3, Kostrova T.A.3
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隶属关系:
- Pavlov Institute of Physiology
- Russian Academy of Sciences
- Institute of Toxicology of the Federal Medical Biological Agency
- 期: 编号 2 (2020)
- 页面: 48-53
- 栏目: Articles
- ##submission.datePublished##: 15.05.2020
- URL: https://rjsocmed.com/0869-7922/article/view/641227
- DOI: https://doi.org/10.36946/0869-7922-2020-2-47-52
- ID: 641227
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详细
An urgent problem is the search for substances that can provide a protective effect in cases of DNA synthesis and repair disorders that arise as a result of side effects of cytostatic drugs used in the treatment of cancer. The aim of this work was to study the effect of 20 encoded amino acids in the presence of Cyclophosphane on the development of organotypic culture of rat liver tissue. The results obtained indicate that Cyclophosphane; which simulates the action of such cytostatic substances; inhibits cell proliferation in the liver tissue. It was also found that the encoded amino acids: asparagine; arginine; and glutamic acid; eliminate the inhibitory effect of Cyclophosphane in liver tissue culture. The growth zone of explants after combined exposure to Cyclophosphane (whose isolated action suppressed the growth zone) and these amino acids increased significantly and reached control values. Thus; the experimental data create the basis for the development of methods for the therapeutic use of the three studied amino acids for the removal of side effects in the treatment with cytostatic drugs.
作者简介
N. Chalisova
Pavlov Institute of Physiology; Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ni_chalisova@mail.ru
Chalisova Natalia Iosifovna
199034; Saint Petersburg
俄罗斯联邦V. Kozlov
Institute of Toxicology of the Federal Medical Biological Agency
Email: kvk52@mail.ru
Kozlov Victor Konstantinovich
192019; Saint Petersburg
俄罗斯联邦A. Mulik
Institute of Toxicology of the Federal Medical Biological Agency
Email: mulikab@mail.ru
Mulik Alexander Borisovich
192019; Saint Petersburg
俄罗斯联邦E. Zatsepin
Institute of Toxicology of the Federal Medical Biological Agency
Email: institute@toxicology.ru
Zatsepin Eduard Pavlovich
192019; Saint Petersburg
俄罗斯联邦T. Kostrova
Institute of Toxicology of the Federal Medical Biological Agency
Email: tasia.pcma.le4@mail.ru
Kostrova Taisiya Alexandrovna
192019; Saint Petersburg
俄罗斯联邦参考
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