ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES

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The resorptive effects of 0.01 M cerium nanodioxide sol upon single intraperitoneal administration to rats have been studied. The acute exposure to nanoparticles was found to have a dose-dependent general toxic effect on the body (weight loss, inflammatory changes in the abdominal organs, modification of individual behavior, hematological changes, metabolic imbalance), which develops on the background of POL activation. The prooxidant effect of cerium dioxide nanoparticles is demonstratively manifested at relatively high exposure levels (80–8 mg / kg). The threshold dose for the general toxic effect (Limch integr) is equal to 0.8 mg / kg.

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N. Khodykina

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

编辑信件的主要联系方式.
Email: hodykina@rihtop.ru

Khodykina Nina Vladimirovna

400048, Volgograd

俄罗斯联邦

L. Tochilkina

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: tochilkina@rihtop.ru

Tochilkina Lyudmila Petrovna

400048, Volgograd

俄罗斯联邦

O. Novikova

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: novikova@rihtop.ru

Novikova Olga Nikolaevna

400048, Volgograd

俄罗斯联邦

M. Sroslov

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: SroslovMS@gmail.com

Sroslov Mikhail Sergeyevich

400048, Volgograd

俄罗斯联邦

A. Pocheptsov

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: pochepcov@rihtop.ru

Pocheptsov Alexander Yakovlevich

400048, Volgograd

俄罗斯联邦

Yu. Velikorodnaya

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: velikorodnaya@rihtop.ru

Velikorodnaya Julia Ivanovna

400048, Volgograd

俄罗斯联邦

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版权所有 © Khodykina N.V., Tochilkina L.P., Novikova O.N., Sroslov M.S., Pocheptsov A.Y., Velikorodnaya Y.I., 2019


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