ASSESSMENT OF TOXICITY AND HAZARD OF TECHNICAL PRODUCT OF TRIAZINONE’S DERIVATIVE
- Autores: Rakitskii V.N.1, Еpishina T.M.1, Chkhvirkiya E.G.1, Sinitskaya TA.1, Mukhina Е.A.2
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Afiliações:
- F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
- .F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
- Edição: Nº 1 (2019)
- Páginas: 39-42
- Seção: Articles
- ##submission.datePublished##: 28.02.2019
- URL: https://rjsocmed.com/0869-7922/article/view/641151
- DOI: https://doi.org/10.36946/0869-7922-2019-1-39-42
- ID: 641151
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Resumo
Experimental assessment of toxicity and hazard of technical product of triazinone’s derivative at its peroral administration into warm-blooded animals’ bodies (male rats) has been conducted to determine the character of the substance biological action. Its acute peroral toxicity was at the level of LD50 -1693 ± 470 mg/kg of body weight, hazard class – 4 according to Hygienic Classification of Pesticides (Sanitary Rules & Standards 1.2.2584-10). Effective dose was 62.5 mg/kg b.w., non-effective dose (NOEL) was 12.5 mg/kg b.w. ADI was 0.1 mg/kg b.w.
Sobre autores
V. Rakitskii
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Autor responsável pela correspondência
Email: pesticidi@yandex.ru
Rakitskii Valery Nikolaevich
141014, Mytishchi, Moscow Region,
RússiaT. Еpishina
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Email: pesticidi@yandex.ru
Epishina Tatiana Mihailovna
141014, Mytishchi, Moscow Region,
RússiaE. Chkhvirkiya
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Email: pesticidi@yandex.ru
Chkhvirkiya Elena Grigor'evna
141014, Mytishchi, Moscow Region,
RússiaT Sinitskaya
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Email: pesticidi@yandex.ru
Sinitskaya Tat'yana Alekseevna
141014, Mytishchi, Moscow Region,
RússiaЕ. Mukhina
.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Email: pesticidi@yandex.ru
Mukhina Ekaterina Aleksandrovna
141014, Mytishchi, Moscow Region,
RússiaBibliografia
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- Pavlenko S.M. Application of summation-threshold index in toxicological experiment on white rats. Methodic of sanitary-toxicological experiment: scientific works collections of MNIIG named after F.F.Erisman. M. 1975; 5-
- Methodical recommendation on using reaction of animals’ behaviour in toxicological researches for hygienic standartization. Kiev. 1980; 47 p.
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