New hyperbranched zwitterionic sorbents for HPLC and methods for controlling their separation capacity

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Resumo

A series of sorbents based on silica gel with zwitterionic functional layers attached via a spacer based on 1,4-butanediol diglycidyl ether was synthesized. The influence of structural fragments of the stationary phase on chromatographic properties in hydrophilic interaction chromatography was studied, and the multifunctional separation capabilities for neutral polar, hydrophobic, and negatively charged compounds were demonstrated. Based on the identified patterns, a sorbent with high separation capacity for carboxylic acids was developed, enabling the separation of 13 organic acids in 25 minutes with a resolution of at least 1.0.

Sobre autores

A. Chernobrovkina

Department of Chemistry, Lomonosov Moscow State University

Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

D. Kryzhanovskaya

Department of Chemistry, Lomonosov Moscow State University

Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

A. Uzhel

Department of Chemistry, Lomonosov Moscow State University

Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

N. Sobolev

Department of Chemistry, Lomonosov Moscow State University

Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

G. Tsizin

Department of Chemistry, Lomonosov Moscow State University

Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

O. Shpigun

Department of Chemistry, Lomonosov Moscow State University

Autor responsável pela correspondência
Email: chernobrovkina@analyt.chem.msu.ru
Moscow, 119991, Russia

Bibliografia

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