Метилирование ДНК при аневризме аорты различной локализации

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Аннотация

Аневризма аорты (АА) – жизнеугрожающее патологическое состояние, осложнение которого в виде разрыва аорты в отсутствие экстренного хирургического вмешательства приводит к летальному исходу. В развитие АА вносят вклад генетические (чаще при торакальной АА – ТАА) и средовые (при ТАА и абдоминальной АА – ААА) факторы. В настоящем обзоре обобщены данные научных публикаций, посвященных изучению метилирования ДНК при воздействии факторов риска АА, а также в клетках различных отделов аорты (грудной, брюшной) в норме и при патологических состояниях. Изменение метилирования ДНК наблюдается в клетках аорты и/или крови при наличии факторов риска АА (артериальная гипертензия, курение, возраст, наличие сопутствующих заболеваний). Исследования метилирования ДНК при ТАА и ААА немногочисленны, проводились с использованием различных подходов к формированию выборок, выбору образцов клеток и экспериментальных методов. Однако они убедительно свидетельствуют об измененном статусе метилирования ДНК генов, выбранных для исследования с использованием кандидатного подхода (при исследовании ААА), а также различных регионов генома при проведении широкогеномного анализа метилирования ДНК (преимущественно при исследовании ТАА). Гены, локализованные в дифференциально-метилированных регионах, связаны с функционированием сердечно-сосудистой системы, вовлечены в клеточные и метаболические процессы, патогенетически значимые для развития АА. В ряде случаев установлена связь уровней метилирования ДНК с клиническими параметрами при АА. Эти результаты указывают на перспективность расширения исследований метилирования ДНК при АА, в том числе и с целью выявления новых патогенетически значимых звеньев при развитии АА.

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А. Н. Кучер

Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук

Email: maria.nazarenko@medgenetics.ru
Россия, Томск 634050

С. А. Шипулина

Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук

Email: maria.nazarenko@medgenetics.ru
Россия, Томск 634050

И. А. Гончарова

Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук

Email: maria.nazarenko@medgenetics.ru
Россия, Томск 634050

М. С. Назаренко

Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук

Автор, ответственный за переписку.
Email: maria.nazarenko@medgenetics.ru
Россия, Томск 634050

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